Anti-LIS1抗體,無腦回的致病基因LIS1抗體產品介紹：Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates plaet-activating factor (PAF) by removing the acetyl group at the SN-2 position. 

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保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
連續使用時4°C存儲，保質期六個月，*存儲時建議分裝為10ul以上小包裝-20°C存儲，并避免反復凍融，保質期一年。

產品名稱 Anti-LIS1抗體,無腦回的致病基因LIS1抗體

產品編號 BYK-2035R

英文名稱 LIS1
中文名稱 無腦回的致病基因LIS1抗體
別    名 LIS 1; LIS 2; LIS-1; LIS1; LIS1_HUMAN; LIS2; Lissencephaly 1 protein; Lissencephaly-1 protein; MDCR; MDS; PAF acetylhydrolase 45 kDa subunit; PAF AH 45 kDa subunit; PAF AH alpha; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; PAFAH; PAFAH1B1; PAFAHA; Plaet activating factor acetylhydrolase 1b regulatory subunit 1; Plaet activating factor acetylhydrolase isoform Ib alpha subunit; Plaet-activating factor acetylhydrolase IB subunit alpha.
研究領域 細胞生物  神經生物學  信號轉導     

抗體來源 Rabbit or Mouse
克隆類型 Polyclonal or Monoclonal
交叉反應、產品應用 （具體交叉反應與產品應用請）

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