肝羧酸酯酶1抗體,Anti-CES1抗體簡單介紹：

產品編號：BYK-18301R

英文名稱：Anti-CES1
中文名稱：肝羧酸酯酶1抗體

別名：ACAT; Acyl coenzyme A cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxyesterase ES-3; Carboxylesterase; Carboxylesterase 1 (monocyte/macrophage serine esterase 1); Carboxylesterase 1; Carboxylesterase 1 deficiency, included; Carboxylesterase 2, formerly; CE 1; CEH; Ces-1; Ces1; CES2; CESDD1; Cholesterol ester hydrolase, neutral, macrophage-derived; Cholesteryl ester hydrolase; Cocaine carboxylesterase; EC 3.1.1.1; Egasyn; ES-H; ES-x; Es22; EST1_HUMAN; Esterase 22; Esterase; hCE 1; HMSE; HMSE1; Liver carboxylesterase 1; Liver carboxylesterase 3; Methylumbelliferyl acetate deacetylase 1; MGC117365; MGC156521; Monocyte carboxylesterase deficiency, included; Monocyte esterase deficiency, included; Monocyte/macrophage serine esterase; PCE-1; pI 5.5 esterase; Proline-beta-naphthylamidase; REH; Retinyl ester hydrolase; Serine esterase 1; Ses-1; SES1

背景介紹：This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. 

產品規格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

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性    狀 Lyophilized or Liquid
濃    度 1mg/ml

肝羧酸酯酶1抗體,Anti-CES1抗體產品信息：

免疫應答

    抗原刺激機體產生相應的抗體，抗體的產生過程即為體液免疫應答過程。

    體液免疫應答的主要*位是淋巴結、脾臟和粘膜下淋巴組織等外周免疫器官，外來抗原進入機體后即被補體致敏或者被DC吞噬，然后隨淋巴液進入引流淋巴結。淋巴濾泡中的FDC通過其表面的補體受體捕獲被致敏的外來抗原，激活B細胞。位于脾髓質交界區的DC則為T細胞呈遞外來抗原肽，啟動獲得性免疫應答，B細胞在外周成熟、發育過程的zui后階段是成為專門的合成和分泌抗體分子的漿細胞。漿細胞高爾基體發達、代謝活躍，但沒有繼續分裂、增殖的能力，也不參與抗原遞呈。他們寄居在脾臟或者骨髓中，集中所有的能量生產并分泌抗體分子?？贵w分子的重鏈和輕鏈在內質網上合成、組裝后經高爾基體運輸至細胞表面并分泌于胞外。一個漿細胞每秒鐘能分泌5000個抗體分子，在外周的漿細胞壽命僅為幾天，但是骨髓中的漿細胞壽命可能較長。

免疫應答過程：

1.抗原進入機體；

2.抗原刺激 B淋巴細胞，使之分化增殖成為抗體分泌漿細胞和記憶細胞（初次免疫應答）；

3.抗體主要由漿細胞分泌 ；

4.記憶細胞再次受到特異性抗原刺激后會被激活而成為分泌抗體的漿細胞（再次免疫應答）；

5.記憶B細胞是長命細胞，可以存活數月甚至機體終生

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